F-actin

When the two plectin CH domains can separate, the affinity for F-actin is approximately three times greater than when the two CH domains are cross-linked (the disulfide cross-link is indicated by the space filling atoms at the CH1-CH2 interface) in a closed conformation Affiliations

Naturejobs - All Jobs Vitold E Galkin 2010

Crystal structures have shown the tandem CH domains of α-actinin to be in a compact, closed conformation, but the interpretations of complexes of such tandem CH domains with F-actin have been ambiguous.

Naturejobs - All Jobs Vitold E Galkin 2010

We also found that Mical utilizes its redox activity to alter F-actin dynamics in vivo and in vitro, indicating a previously unknown role for specific redox signalling events in actin cytoskeletal regulation.

Naturejobs - All Jobs Ruei-Jiun Hung 2010

This photograph shows the F-actin of the cell at 0, 1, 6, and 12 h after wounding with or without 100 ng/ml bFGF.

PLoS ONE Alerts: New Articles Shigeyuki Kanazawa et al. 2010

Likewise, we purified Mical protein and found that it directly binds F-actin and disassembles both individual and bundled actin filaments.

Naturejobs - All Jobs Ruei-Jiun Hung 2010

Here we report that Mical directly links semaphorins and their plexin receptors to the precise control of actin filament (F-actin) dynamics.

Naturejobs - All Jobs Ruei-Jiun Hung 2010

Confocal immunofluorescent localization of BCL2 and F-actin during spreading consistently showed that increased expression of BCL2 resulted in increased F-actin polymerization.

Naturejobs - All Jobs Hengning Ke 2010

Confocal immunofluorescent localization of BCL2 and F-actin during spreading consistently showed that increased expression of BCL2 resulted in increased F-actin polymerization.

Naturejobs - All Jobs Hengning Ke 2010

Confocal immunofluorescent localization of BCL2 and F-actin during spreading consistently showed that increased expression of BCL2 resulted in increased F-actin polymerization.

Naturejobs - All Jobs Hengning Ke 2010

We found that Mical is both necessary and sufficient for semaphorin-plexin-mediated F-actin reorganization in vivo.

Naturejobs - All Jobs Ruei-Jiun Hung 2010