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Examples
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Read more: Jake Gyllenhaal Reese Witherspoon, Jake Gyllenhaal, Jake Gyllenhaal GQ, Reese Witherspoon, Ryan Phillipe, Gq, Entertainment News
Jake Gyllenhaal In GQ: Life After Reese Is 'Okay' The Huffington Post News Team 2010
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"reset," a cascade of reactions known as Gq signaling leads to scar tissue formation, hypertrophy and heart failure.
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In one experiment for the current study, researchers artificially stimulated the Gq chemical pathway in mice lacking RGS2, worsening the effects of Gq signaling, including hypertrophy and widened heart chambers.
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Subsequent protein analysis for enzymatic action common to heart failure showed the same results for both sets of mice, confirming to researchers that RGS2 proteins were responsible for protecting the heart from hypertrophy linked to Gq signaling.
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These data suggest that, in addition to their retrograde neurotransmitter role, endocannabinoids have much broader paracrine mediator functions during activation of Gq/11-coupled receptors.
Journal of Biological Chemistry current issue Turu, G., Varnai, P., Gyombolai, P., Szidonya, L., 2009
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"The evidence is piling up that unbridled Gq signaling is driving a central biological chain reaction in heart failure," says Kass, "and that by extending the protective effects of RGS2 or by developing a test for its presence, researchers can develop new therapies or improve existing ones, including ACE inhibitors and possibly sildenafil, for people with heart failure who will benefit most."
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Gq and Gi subtypes activate adenylate cyclase (AC), which modulates the production of cAMP.
GEN News Highlights 2009
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Currently, physicians use so-called ACE inhibitor and ARB inhibitor drugs to block Gq signaling.
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Doctors currently use so-called ACE inhibitor and ARB inhibitor drugs to block Gq signaling.
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In another experiment in mice with and without RGS2, researchers analyzed the cardiac response to the physical stress of twice daily swimming exercises lasting 90 minutes each, a stress not known to affect Gq signaling.
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