Definitions
from Wiktionary, Creative Commons Attribution/Share-Alike License.
- initialism 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine
- noun A byproduct of synthetic
heroin , orMPPP , which causes Parkinsonian symptoms in users. - noun A
neurotoxin which degrades intoMPP+ after crossing the blood brain barrier, which causes a degredation of thedopaminergic neurons within thesubstantia nigra .
Etymologies
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Examples
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In one experiment Walsh and his team injected mice with a toxin, called MPTP, that induces Parkinson's disease by killing off dopaminergic neurons.
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Tieu, who initiated the study as a post-doctoral research associate in the laboratory of Dr. Serge Przedborski, the Page and William Black Professor of Neurology at Columbia University, has revealed that they chose to study how the brain handles a chemical known as MPTP, which ultimately damages the exact same brain cells that are injured in patients with Parkinson's disease.
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In addition, toxins such as MPTP and rotenone, which are believed to increase reactive oxygen species from complex I of the electron transport chain, can induce a parkinsonian syndrome in humans and animal models
PLoS Biology: New Articles Derek P. Narendra et al. 2010
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In a recently completed study using the "MPTP" primate model, all doses of ADX10059 abolished levodopa induced dyskinesia in the first hour after levodopa administration.
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MPTP, which is converted to the complex I inhibitor 1-methyl-4-phenylpyridine (MPP
PLoS ONE Alerts: New Articles Nadia G. Innamorato et al. 2010
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As an MPTP for Prudential I interacted in the day to day activities assisting managers at the company.
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The other issue is MPTP (marginal propensity to post).
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As an MPTP for Prudential I interacted in the day to day activities assisting managers at the company.
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The other issue is MPTP marginal propensity to post.
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MPTP produces a "Parkinson-like disease" by damaging neurons in an area of the midbrain (substantia nigra).
Neurotoxicity 2008
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