Definitions
Wiktionary
- 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine
- n. A byproduct of synthetic heroin, or MPPP, which causes Parkinsonian symptoms in users.
- n. A neurotoxin which degrades into MPP+ after crossing the blood brain barrier, which causes a degredation of the dopaminergic neurons within the substantia nigra.
Examples
“In one experiment Walsh and his team injected mice with a toxin, called MPTP, that induces Parkinson's disease by killing off dopaminergic neurons.”
“Tieu, who initiated the study as a post-doctoral research associate in the laboratory of Dr. Serge Przedborski, the Page and William Black Professor of Neurology at Columbia University, has revealed that they chose to study how the brain handles a chemical known as MPTP, which ultimately damages the exact same brain cells that are injured in patients with Parkinson's disease.”
“In addition, toxins such as MPTP and rotenone, which are believed to increase reactive oxygen species from complex I of the electron transport chain, can induce a parkinsonian syndrome in humans and animal models”
“In a recently completed study using the "MPTP" primate model, all doses of ADX10059 abolished levodopa induced dyskinesia in the first hour after levodopa administration.”
“MPTP, which is converted to the complex I inhibitor 1-methyl-4-phenylpyridine (MPP”
“The other issue is MPTP (marginal propensity to post).”
“As an MPTP for Prudential I interacted in the day to day activities assisting managers at the company.”
“The other issue is MPTP marginal propensity to post.”
“MPTP produces a "Parkinson-like disease" by damaging neurons in an area of the midbrain (substantia nigra).”
“Hope for a neuroprotective effect of CoQ 10 was based in part on animal experiments in which mice with MPTP induced Parkinsonian symptoms were shown to have reduced loss of dopaminergic axons when treated with Coenzyme Q.”
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