Definitions

from Wiktionary, Creative Commons Attribution/Share-Alike License

  • n. a protein found in vertebrates such as humans, mice and chickens

Etymologies

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Examples

  • It is expected that inhibition of N-cadherin would have the same the effect in cancer cells, which also move in groups during metastasis.

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  • Scientists blocked surface molecules, proteins called N-cadherin, on the neural crest cells that are involved in forming contacts between cells.

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  • Green, mCD8-GFP, labeling LN processes; red, synaptotagmin-HA, a marker for presynaptic terminals; blue, nc82 or N-cadherin staining, highlighting glomerular structures.

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  • (DOR) promotes the processing of Aβ precursor protein (APP) by BACE1 and γ-secretase, but not that of Notch, N-cadherin or APLP.

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  • The altered cell survival induced by N-cadherin overexpression is Wnt - and PI3K/Akt-dependent.

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  • Tibias from 1.5 month old female N-cadherin transgenic and wild type mice and primary osteoblasts isolated from calvarias by sequential collagenase digestion were obtained as described

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  • To determine the functional relevance of these findings, we tested the effects of ERK and PI3K inhibitors on cell proliferation induced by Wnt. As shown in N-cadherin overexpression negatively regulates ERK and PI3K signalling.

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  • Finally, we found that the decreased cell survival induced by N-cadherin overexpression was reversed by Wnt and antagonized by PI3K inhibition.

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  • Mechanisms by which N-cadherin decreases cell survival.

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  • The Wnt inhibitor DKK1 abolishes ERK and PI3K signalling restored by N-cadherin blockade.

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