Definitions

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  • n. Plural form of aggresome.

Etymologies

Sorry, no etymologies found.

Examples

  • In neurodegenerative disorders such as Alzheimer's, Huntington's and Parkinson's, intracellular deposition of aggregated proteins into inclusion bodies, Lewy bodies, or aggresomes is a prominent cytopathological feature

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  • This accumulation in aggresomes may prevent processing of MstnPP and decrease levels of circulating growth factor, as mature myostatin growth factor is absent in immunoblots of CHMFs transiently expressing AβPP

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  • Even though MstnPP aggregates were localised to the cytoplasm, aggresomes and nuclear regions of sIBM tissue in previous studies

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  • Johnston JA, Illing ME, Kopito RR (2002) Cytoplasmic dynein/dynactin mediates the assembly of aggresomes.

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  • Increased activity of the myostatin growth factor following MstnPP upregulation may contribute to atrophy in sIBM, however another study showed MstnPP accumulated with Aβ/AβPP within aggresomes following ER stress by proteasome inhibition in CHMFs

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  • Cultured human muscle fibers (CHMFs) overexpressing Aβ precursor protein showed an increase in MstnPP protein levels and subsequent experimental inhibition of the proteasome caused co-accumulation of MstnPP and AβPP/Aβ within aggresomes

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  • Our results establish that aggresomes are not obligatory products of protein misfolding in vivo.

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  • In contrast to aggresomes, the formation of dispersed aggregates is insensitive to histone deacetylase 6 inhibitors and does not result in cytoskeleton rearrangements.

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  • Yet, why aggresomes are not a pathological characteristic of protein misfolding diseases is unclear.

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  • Here, we investigate if a misfolded protein inevitably forms aggresomes in mammalian cells.

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