Definitions
from Wiktionary, Creative Commons Attribution/Share-Alike License.
- noun Plural form of
beta-lactamase .
Etymologies
Sorry, no etymologies found.
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Examples
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In Pseudomonas aeruginosa, secondary beta-lactamases with extended substrate specificity can be responsible for acquired resistance to the most powerful antipseudomonal beta-lactams, such as expanded-spectrum cephalosporins and carbapenems.
Behe's Test 2008
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A review of different types of known beta-lactamases.
Axe (2004) and the evolution of enzyme function - The Panda's Thumb 2007
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This is pertinent for penicillinases, that are beta-lactamases.
Axe (2004) and the evolution of enzyme function - The Panda's Thumb 2007
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We know of a number of other families of structures that include beta-lactamases Helfand and Bonomo, 2003.
Axe (2004) and the evolution of enzyme function - The Panda's Thumb 2007
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Antibiotics such as penicillin are called, collectively, beta-lactams, and enzymes that break down these antibiotics and confer drug resistance are called beta-lactamases, which is why the term beta-lactamase may pop up in this blog entry from time to time.
Axe (2004) and the evolution of enzyme function - The Panda's Thumb 2007
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Second, a set of hybrid sequences is constructed from the 50 %-identical TEM-1 and Proteus mirabilis beta-lactamases.
"Intro to ID" by Gonzalez at U of Northern Iowa - The Panda's Thumb 2005
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LAS 977 is very important, inhaled once daily, longer acting beta-lactamases.
Forest Laboratories Q3 2011 Earnings Call Transcript - Seeking Alpha 2011
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NXL 104 covers a broad range of beta-lactamases, including a standard spectra beta-lactamases, PSBL.
Forest Laboratories Q3 2011 Earnings Call Transcript - Seeking Alpha 2011
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It overcomes bacterial resistance by several mechanisms and is not easily destroyed by bacterial beta-lactamase enzymes, such as extended-spectrum beta-lactamases (ESBLs), carbapenemases and the recently characterized New Delhi metallo-beta-lactamase 1 (NDM-1), which cause resistance against many currently marketed antibiotics.
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It can potentially be combined with various beta-lactam antibiotics to enhance the spectrum of activity and counteractive resistance especially in gram-negative pathogens which are the one most commonly-producing beta-lactamases.
Forest Laboratories Q3 2011 Earnings Call Transcript - Seeking Alpha 2011
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