American Heritage® Dictionary of the English Language, Fourth Edition
- n. A site in the autonomic nervous system in which inhibitory responses occur when adrenergic agents, such as norepinephrine and epinephrine, are released. Activation of beta-receptors causes various physiological reactions, such as relaxation of the bronchial muscles and an increase in the rate and force of cardiac contraction. Also called beta-adrenergic receptor.
“Overuse of the beta-agonists has well described as reason to down regulate the beta-receptor.”
“I saw that the success of the beta-receptor antagonist programme would suck me more and more into the role of giving the young propranolol technical support and promotion - just as I was itching to start a new programme.”
“Among the numerous people who were involved in bringing the first beta-receptor antagonist to the marketplace, three played crucial roles.”
“I was convinced that the histamine antagonists of the day were analogous to the alpha-receptor antagonists and that the equivalent of a beta-receptor antagonist was needed to block, for example, histamine-stimulated acid secretion.”
“Black's ideas were correct, and beta-receptor blocking drugs have subsequently been widely used in the treatment of angina pectoris and conditions with tachycardia and tachyarrythmia.”
“H2-antagonists discovered by Black selectively inhibit gastric secretion, while beta-receptor antagonists inhibit cardiac and pulmonary actions of epinephrine and norepinephrine.”
“Ahlqvist's receptor theory stimulated Black and coworkers to develop substances with beta-receptor blocking properties in”
“Black was the first to realize that the development of a clinically useful beta-receptor blocking drug might introduce a new pharmacotherapeutic principle in the treatment of coronary heart disease (angina pectoris).”
“Using the isoprenaline molecule as a basis Black and coworkers succeeded in developing the first clinically useful beta-receptor antagonists pronethalol (1962) and propranolol (1964).”
“A beta-receptor blocking compound had been developed by other researchers in 1958, but it was only suitable for experimental studies in animals.”
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