Definitions

from Wiktionary, Creative Commons Attribution/Share-Alike License

  • n. Either of several forms of keratin found in the intracytoplasmic cytoskeleton of epithelial tissue.

Etymologies

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Examples

  • Expression of Cre and hence targeting of the floxed gene can be restricted to e.g. T cells (lck promoter), cardiac muscle (cardiac myosin promoter), neurons (enolase promoter) or epithelia (cytokeratin promoter).

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  • Before any tissue dissociation procedure, the biopsies were characterised immunohistochemically with anti-CEA (carcinoembryonic antigen) and anti-cytokeratin antibodies as a positive control.

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  • We also used immunohistochemistry to detect annexin IV and cleavage of cytokeratin 18 as markers of trophoblast apoptosis.

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  • DNA-nick end labeling (TUNEL) assay, immunofluorescence for active caspase 3, immunohistochemistry for annexin IV, and the appearance of a cytokeratin 18 neoepitope (M30) produced downstream from caspase proteolytic action

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  • Basal-like breast cancer has similarities with normal breast basal epithelial cells and is commonly identified by a lack of ER and HER2 receptor expression and by the expression of either cytokeratin 5/6 or epidermal growth factor receptor

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  • HER2 receptors and also cytokeratin 5/6 and EGFR ( "triple-negative tumors that are not basal-like").

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  • Numerous studies have shown that immunohistochemistry for hormone and EGFR receptors and cytokeratin 5/6 expression is a simple and workable way to determine the intrinsic subtype of breast tumors for clinical applications

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  • Among these, 77. 1% (27/35) were defined as basal-like by immunostaining specific for the established surrogate markers cytokeratin (CK) 5/6 and/or EGFR.

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  • In the cohort of the differentially expressed proteins identified by mass spectrometry, cytokeratin 8 (CK8), was further validated by immunostaining of freshly isolated cells and frozen tissue sections using monoclonal antibodies.

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  • The duct is mainly comprised of cytokeratin-positive (CK+) epithelial cells, with rare proliferating cells, a limited number of cells that express the early pancreatic development marker, Pdx-1, and rare duct-associated ICCs.

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