Definitions

from Wiktionary, Creative Commons Attribution/Share-Alike License

  • n. Any of a family of polypeptides, isolated from venom, that interact with integrin proteins and inhibit the clumping of platelets

Etymologies

Sorry, no etymologies found.

Examples

  • Adamts5 (a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 5 (aggrecanase-2)) was found in UD

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  • The first is catalyzed by a metalloprotease of the ADAM (a disintegrin and metalloprotease) family

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  • Brou C, Logeat F, Gupta N, Bessia C, LeBail O, et al. (2000) A novel proteolytic cleavage involved in Notch signaling: the role of the disintegrin-metalloprotease TACE.

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  • US-based researchers Alireza Sadeghnejad, Jill Ohar, Eugene Bleecker and colleagues from the Wake Forest School of Medicine and Saint Louis University, looked at a disintegrin and metalloprotease (ADAM) gene known as ADAM33 in 880 long-term heavy smokers.

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  • For the study, US-based researchers Alireza Sadeghnejad, Jill Ohar, Eugene Bleecker and colleagues from the Wake Forest School of Medicine and Saint Louis University looked at a disintegrin and metalloprotease (ADAM) gene known as ADAM33 in 880 long-term heavy smokers.

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  • Llamazares M, Garabaya C, Quesada V, et al. (2002) Cloning, expression analysis and structural characterization of seven novel human ADAMTSs, a family of metalloproteinases with disintegrin and thrombospondin-1 domains.

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  • With respect to gonadal function, Adamts19 (a disintegrin and metalloproteinase domain, with thrombospondin type-1 modules), significantly up-regulated in 20\% CR, 40\% CR and HFG diets, has been shown to be expressed in multiple tissues, and in particular the testes

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  • Furthermore, we show in mice and in human cartilage explants that pharmacological or genetic inhibition of Hh signaling reduces the severity of osteoarthritis and that runt-related transcription factor-2 (RUNX2) potentially mediates this process by regulating a disintegrin and metalloproteinase with thrombospondin type 1 motif-5 (ADAMTS5) expression.

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  • These multifaceted molecules bear metalloproteinase and disintegrin domains endowing them with features of both proteinases and adhesion molecules.

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  • The ADAM (a disintegrin and metalloprotease) family proteins play critical roles in morphogenesis, fertilization, and diseases.

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