from The American Heritage® Dictionary of the English Language, 4th Edition
- n. A calcium-dependent actin-binding protein that modulates actin filament length and gelation and thus influences the structure of the cytoskeleton and plays a key role in cellular motility and differentiation.
from Wiktionary, Creative Commons Attribution/Share-Alike License
- n. An actin-binding protein that is a key regulator of actin filament assembly and disassembly.
Arai M, Bandura JL, Kwiatkowski DJ (1998) Advillin (p92): a new member of the gelsolin/villin family of actin regulatory proteins.
The mechanism of BCL2 regulation of cell adhesion and motility may involve formation of a complex containing BCL2, actin, and gelsolin, which appears to functionally decrease the severing activity of gelsolin.
Thus, the formation of BCL2 and gelsolin complexes (which possibly contain other proteins) appears to play a critical role in the regulation of cell adhesion and migration.
Then there’s gelsolin, glyceraldye 3 phosphate dehydrogenase, alpha enolase, argininosuccinate lyase, NADPH dependent reductase.
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