from Wiktionary, Creative Commons Attribution/Share-Alike License
- n. Any agent that causes hypermutation
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Thus, patients who initially respond to temozolomide may evolve not only treatment resistance but also a hypermutator phenotype (since DNA repair genes have been mutated).
By integrating methylation data, somatic mutation data and clinical treatment data, scientists identified a relationship between MGMT methylation and a hypermutator phenotype described previously .
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