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Previous studies have suggested that early life experiences can influence the development of regulatory systems implicated in the pathophysiology of chronic fatigue syndrome, including the hypothalamic-pituitary-adrenal axis, according to the researchers.— MedPageToday.com - medical news plus CME for physicians
Specifically, dysfunction of the hypothalamic-pituitary-adrenal axis -- the body's main neuroendocrine stress response system -- leads to lower-than-normal cortisol concentrations and insufficient glucocorticoid signaling, which is associated with "increased immune activation and inflammatory responses, potentially promoting symptoms of fatigue and pain," they said.— MedPageToday.com - medical news plus CME for physicians
A nuclear receptor, NR5A1 (also called steroidogenic factor 1), is a key transcriptional regulator of genes involved in the hypothalamic-pituitary-steroidogenic axis.— New England Journal of Medicine
The impact of such exposures on the hypothalamic-pituitary-gonadal axis and subsequent sexual maturation is the subject of the present review.— CiteULike: Everyone's library
We discuss biomarkers of the cardiovascular system, metabolic processes, inflammation, activity in the hypothalamic-pituitary axis (HPA) and sympathetic nervous system (SNS), and organ functioning— CiteULike: Everyone's library

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