Definitions
from Wiktionary, Creative Commons Attribution/Share-Alike License.
- noun biology Any of various
karyopherins that move otherprotein molecules into thecell nucleus bybinding to a specificrecognition sequence .
Etymologies
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Examples
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November 10, 2007 at 1:26 pm it r importin two teh lolpeepz anyway. mutsh uv vot we awl duz r nawt importin two otehrs, awr nawt eefin importin at awl. iz okay — wateffer maek yu happi r importin two yu.
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But, says sum folks, if you stop importin 'things you stop the revenoo.
Artemus Ward 1865
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Tu LC, Musser SM (2008) Single-molecule measurements of importin alpha/cargo complex dissociation at the nuclear pore.
PLoS ONE Alerts: New Articles Francesco Cardarelli et al. 2010
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Primary cells express lower levels of nuclear pore complex proteins and the nuclear transport factors, importin B1 and importin 7, which may explain the limiting ERK1/2 import found in primary cells.
Elites TV PLoS ONE 2010
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We show here that regulated nuclear import of p53 also has a critical function. p53 import is mediated by binding to the importin - α3 adapter and is negatively regulated by ubiquitination. p53 harbors several nuclear localization signals (NLS), with the major NLS I located at amino-acids 305-322.
Naturejobs - All Jobs N D Marchenko 2010
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We find that direct binding of p53 to importin - α3 depends on the positive charge contributed by lysine residues 319-321 within NLS I.
Naturejobs - All Jobs N D Marchenko 2010
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These are: importin (12), CDK/cyclin (22), F-actin (12), PARP1
PLoS ONE Alerts: New Articles Vincent Gache et al. 2010
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Conversely, stress-induced accumulation of non-ubiquitinated p53 in the cytoplasm promotes interaction with importin - α3 and rapid import.
Naturejobs - All Jobs N D Marchenko 2010
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Using glutathione S-transferase pulldown experiments, we provide evidence that heterodimers are required for efficient binding of importin 13 because the monomers alone do not significantly interact.
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Our results from in vitro nuclear import assays with permeabilized cells and in vivo cotransfection experiments reveal that importin 13 facilitates nuclear import of both histone fold heterodimers.
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