“Specific cytogenetic alterations and changes in DNA methylation are involved in leukemogenesis.”
“The correlative science that results from this clinical trial will allow Dr. Walker to identify mechanisms of leukemogenesis and further her efforts in the development of experimental therapeutics for patients with this disease.”
“HOXA9, HOXA10 and ID2, were (de) regulated via PRC2 which therefore contributes to T-cell leukemogenesis.”
“In these differentiation processes deregulation of developmental genes may contribute to leukemogenesis.”
“Gene mutation is an important mechanism of myeloid leukemogenesis.”
“TITLE: c-Myb binds MLL through menin in human leukemia cells and is an important driver of MLL-associated leukemogenesis”
“Radiation leukemogenesis in mice: Loss of PU. 1 on chromosome 2 in CBA and C57BL/6 mice after irradiation with 1 GeV/nucleon 56Fe ions, X rays or gamma rays.”
“Radiation leukemogenesis in mice: Loss of PU. 1 on chromosome 2 in CBA and C57BL/6 mice after irradiation with 1 GeV/nucleon 56Fe ions, X rays or gamma Rays.”
“(UCLA) have identified two genes - p16 (Ink4a) and Arf - that sensitize lymphoid progenitor cells to the effects of aging, and confer resistance to leukemogenesis.”
“Kalev-Zylinska ML, Horsfield JA, Flores MV, Postlethwait JH, Vitas MR, et al. (2002) Runx1 is required for zebrafish blood and vessel development and expression of a human RUNX1-CBF2T1 transgene advances a model for studies of leukemogenesis.”
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