Definitions
from Wiktionary, Creative Commons Attribution/Share-Alike License.
- noun Plural form of
ligase .
Etymologies
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Examples
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APG had made good progress with a new process of sequencing that used a technique for gluing strands of DNA together rather than synthesizing new strands, using enzymes called ligases, that bond the fragments together.
The $1,000 Genome Kevin Davies 2010
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Kotorashvilli A, Russo S, Mulugeta S, Guttentag S, Beers M. Anterograde transport of surfactant protein C proprotein to distal processing compartments requires PPDY mediated association with Nedd4-2 ubiquitin ligases.
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Speaking of undersampling, it would have been good to look at the breakdown of common substrates of DD-peptidyl ligases and beta lactamases, such as m-[[phenylacetyl-glycyl]oxy]benzoic acid and see what the muations did to these activities.
Axe (2004) and the evolution of enzyme function - The Panda's Thumb 2007
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Of course a ligase is also a type of enzyme, so for Berlinski to make a claim about ligases while excluding enzymes is nonsensical.
Good Math, Bad Math, and David Berlinkski - The Panda's Thumb 2006
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The complex evolutionary history of HECT ubiquitin ligases in animals has been deciphered.
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Animal HECT ubiquitin ligases: evolution and functional implications
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Proteins of the PIAS family can act as SUMO-3 ligases, significantly enhancing the level of the substrate sumoylation
PLoS ONE Alerts: New Articles Mara Marongiu et al. 2010
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The complex evolutionary history of HECT ubiquitin ligases in animals has been deciphered.
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In outline, sumoylation involves the reversible covalent attachment of a SUMO protein moiety (about 11 kDa) to lysine residues in proteins through a three-step process, engaging the E1-activating molecules SAE1/SAE2, the E2-conjugating enzyme UBC9, and E3 ligases such as PIAS in mammalian cells that confer specificity
PLoS ONE Alerts: New Articles Mara Marongiu et al. 2010
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HECT ubiquitin ligases (HECT E3s) are key components of the eukaryotic ubiquitin-proteasome system and are involved in the genesis of several human diseases.
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