- meth- + oxy- + (tri)chlor(oethane), a chemical compound used in pesticides. (American Heritage® Dictionary of the English Language, Fourth Edition)
“In this study, the authors write: It is worthwhile noting that the lower dose of methoxychlor tested (3 mg/pellet, or approximately 1.2 mg/kg/day) is 4-fold lower than the NOEL used by the U.S. Environmental Protection Agency (EPA) in developing an oral reference dose for methoxychlor.”
“Immunologists, meanwhile, are trying to ascertain what happens to the immune systems of lab mice when they expose them to organochlorine pesticides such as DDT and methoxychlor, the latter having been manufactured as a safer replacement for DDT and now being used widely on food crops, home gardens, and as flea and tick control on pets.”
“This suggests that an effect on autoimmunity might be a sensitive toxic end point an effect that occurs at doses lower than other adverse effects for methoxychlor, and therefore of particular interest for risk assessment.”
“This suggests, say the authors, that the commonly used pesticide methoxychlor might stimulate autoimmunity at a much lower dose than doses necessary to cause other adverse health effects, and is “therefore of particular interest for risk assessment.””
“In a startling experiment published in 2005, scientist Michael Skinner exposed a pregnant rat to two commonly used industrial chemicals: vinclozolin, a fungicide, and methoxychlor, an insecticide.”
“Transient exposure of a gestating female rat during the period of gonadal sex determination to the endocrine disruptors vinclozalin (an antiandrogenic compound) or methoxychlor (an estrogenic compound) induces decreased spermatogenic capacity (cell number and viability) and increased incidence of male infertility in nearly all males of all subsequent generations examined.”
“These include methoxychlor and TDE, neither of which is, on the whole, as useful as DDT but both of which are of value and have an important advantage over DDT in that they are reported to be less toxic to warm-blooded animals.”
“I am sorry to say I don't have any information on these newer materials, like DDT, methoxychlor and parathion.”
“After a year of no spraying, DDT was replaced by methoxychlor in 1964 but residues of DDT and its breakdown products”
“Researchers at the University of California at Davis have performed a thorough examination of the effects of hormone disruption during adolescence was undertaken by exposing female rhesus monkeys to known estrogenic agents methoxychlor and diethylstilbestrol (DES) during puberty (Golub 2003, 2004).”
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