“We use the model to explore the parameter space that allows stem cell maintenance, and to simulate the consequences of mutations, gene misexpression and cell ablations.”
“In plants, this has been achieved by expressing Simulation for WUS misexpression in the stem cell domain.”
“Starting from an equilibrated wild-type meristem, misexpression of”
“However, all previous studies performed on various mutants or constitutive misexpression lines did not allow studying the immediate consequences of system perturbations.”
“Experimental evidence from WUS misexpression shows that only outer cell layers acquire stem cell identity.”
“Contrary to the cascade model of misexpression, we find that there is considerable stage-specific autonomy of regulatory breakdown in hybrids, with the larval and adult stages showing significantly more hybrid misexpression as compared to the pupal stage.”
“However, this has prompted the suggestion that misexpression in adult hybrids results from the downstream cascading effects of a subset of genes improperly regulated in early development.”
“Evidence in favour of this latter hypothesis is supported further by the misexpression of proAtHB8: GUS.”
“Igf1 −/− and Igf1+/+ transcriptomes in E18. 5 mouse cochleae using RNA microchips and validating their results, we demonstrate the up-regulation of the FoxM1 transcription factor and the misexpression of the neural progenitor transcription factors”
“Furthermore, although endogenous SoxB1 limits nuclear β-catenin activity and SoxB1 misexpression strongly antagonizes it, SoxB1 morphants have greatly”
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