mislocalization

In order to gain direct evidence that a mutated di-arginine motif causes mislocalization to the plasma membrane, we co-transfected primary fibroblasts with either wildtype NF-PLN and a

PLoS ONE Alerts: New Articles Parveen Sharma et al. 2010

These data imply that COP I binds directly to the di-arginine motif in PLN, since mutation of this motif results in COP I not binding to PLN RΔ14 and its mislocalization to the plasma membrane.

PLoS ONE Alerts: New Articles Parveen Sharma et al. 2010

Note that mutation of either Arg13 or Arg14, or both together, resulted in mislocalization of PLN out of the ER with significant expression at the plasma membrane.

PLoS ONE Alerts: New Articles Parveen Sharma et al. 2010

Mutations deleting codons for either or both Arg13 or Arg14 resulted in the mislocalization of

PLoS ONE Alerts: New Articles Parveen Sharma et al. 2010

Here we report that mutation or deletion of either arginine in the di-arginine motif results in mislocalization of PLN from the ER.

PLoS ONE Alerts: New Articles Parveen Sharma et al. 2010

Sterol-O-acyltransferase, three proteins identified in our bioinformatic screen also caused mislocalization of these known ER-resident proteins.

PLoS ONE Alerts: New Articles Parveen Sharma et al. 2010

Therefore, depletion of BIN1 at T-tubule membrane after knockdown could result in mislocalization of Cav1. 2, causing inefficient excitation-contraction (EC) coupling and lethal cardiomyopathy.

PLoS Biology: New Articles Ting-Ting Hong et al. 2010

Since localization of L-type calcium channels is critical for synchronous CICR, loss or mislocalization of these channels in the local microenvironment might lead to defective CICR and abnormal heart function.

PLoS Biology: New Articles Ting-Ting Hong et al. 2010

We found by confocal microscopy that mutation or deletion of either or both Arg 13 or Arg 14 caused mislocalization of PLN from the ER.

PLoS ONE Alerts: New Articles Parveen Sharma et al. 2010

The deletion of this sequence results in the mislocalization of SLN.

PLoS ONE Alerts: New Articles Parveen Sharma et al. 2010