“Treatments that imitate this process, called nitrosylation, were tested on cell cultures, human specimens and mice genetically altered to mimic human disease.”
“Several major forms of oxidative modifications can occur on amino acid residue side chains, including carbonylation, nitrosylation, and oxidation of methionine to methionine sulfoxide”
“Yasukawa T, Tokunaga E, Ota H, Sugita H, Martyn JA, et al. (2005) S-nitrosylation-dependent inactivation of Akt/protein kinase B in insulin resistance.”
“S-nitrosylation or nitrosation is the modification of sulfhydryl (- SH) to S-nitroso (- SNO) groups and appears to occur at a molar NO/O”
“Other post-translational modifications of HIF-1α, such as acetylation, phosphorylation and nitrosylation, were also reported, despite contradictory results with regard to their effect on HIF-1α protein stability and transcriptional activity”
“Thomas B, Li X, Pletnikova O, Troncoso JC, et al. (2004) S-nitrosylation of parkin regulates ubiquitination and compromises parkin's protective function.”
“These results implicate neuroinflammation-induced S-nitrosylation / nitration of mitochondrial complex I in mitochondrial malfunction and subsequent degeneration of the nigral dopamine neurons.”
“Furthermore, defect in the mitochondrial respiratory chain, and extensive S-nitrosylation / nitration of mitochondrial complex I were detected prior to the dopaminergic neuronal loss.”
“L-NIL treatment appears to prevent the LPS-induced increase of S-nitrosylation (C, D).”
“Here, we showed that neuroinflammation is able to mediate mitochondrial impairment by S-nitrosylation / nitration of mitochondrial proteins.”
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