- n. Without the state or quality of additivity.
- non- + additivity (Wiktionary)
“The establishment of such a link is sorely needed if we aim for a better understanding of the biological mechanisms underlying intra - and inter-locus additivity and nonadditivity.”
“Here we show that by considering the additivity and nonadditivity features of each genotype explicitly, regulatory biology can be linked to the basic concepts of single locus genetic theory in a straightforward way.”
“Since homoallelic or heteroallelic nonadditivity is a prerequisite for genetic dominance”
“Our analysis suggests that any cis-acting eQTL showing genetic dominance points towards a possible feedback regulation or some other mechanism causing the nonadditivity.”
“In these cases we predict that one will observe heteroallelic nonadditivity, but no homoallelic nonadditivity.”
“This implies that it per definition cannot relate the nonadditivity between alleles in each genotype to the dominance value for RNA and protein phenotypes”
“(eqn. (3)), another prediction is that homozygous loci showing homoallelic nonadditivity are hotspots for the creation of genetic dominant eQTLs in the genome.”
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