Definitions

from Wiktionary, Creative Commons Attribution/Share-Alike License.

  • noun biochemistry A protein which lines the podocytes and whose mutations can cause nephrotic syndrome

Etymologies

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Examples

  • Interaction with podocin and nephrin in the slit diaphragm was shown

    PLoS ONE Alerts: New Articles Saskia F. Heeringa et al. 2009

  • Lichtenberger A, Karle SM, Haas JP, Anacleto FE, et al. (2004) Patients with mutations in NPHS2 (podocin) do not respond to standard steroid treatment of nephrotic syndrome.

    PLoS ONE Alerts: New Articles Saskia F. Heeringa et al. 2009

  • The recent finding that podocin through cholesterol recruitment provides mechanosensitive properties to ion channels such as TRPC6, adds to the notion that the podocyte slit diaphragm relates information into podocyte foot processes

    PLoS ONE Alerts: New Articles Saskia F. Heeringa et al. 2009

  • TRPC6 is an essential component of the podocyte slit diaphragm, where it is integrated into a signaling complex that interacts with nephrin and podocin

    PLoS ONE Alerts: New Articles Saskia F. Heeringa et al. 2009

  • Gribouval O, Roselli S, Benessy F, Lee H, et al. (2000) NPHS2, encoding the glomerular protein podocin, is mutated in autosomal recessive steroid-resistant nephrotic syndrome.

    PLoS ONE Alerts: New Articles Saskia F. Heeringa et al. 2009

  • Villegas G, Teichman J, Mundel P, Tufro A (2006) Autocrine VEGF-A system in podocytes regulates podocin and its interaction with CD2AP.

    PLoS ONE Alerts: New Articles Magali Saint-Geniez et al. 2008

  • Homozygous or compound heterozygous mutations in the podocin gene NPHS2 are found in 10-30\% of pediatric cases of steroid resistant nephrosis and / or FSGS.

    BioMed Central - Latest articles Alexander Needham Stephen J Tonna 2008

  • Expression of NPHS2 (podocin), GSTA1 (Glutathione S-transferase α1), DUSP9 (Dual-specificity phosphatase 9), PTGER1 (Prostaglandin E receptor 1), KCNJ1 (Renal outer medullary potassium channel, ROMK1) and MUC1 (Mucin 1) in 60 normal samples was standardized either by the reference gene RPLP1 (blue points) or by SF (pink points).

    PLoS ONE Alerts: New Articles Antoine Disset et al. 2009

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