from The American Heritage® Dictionary of the English Language, 4th Edition
- n. Any of various mainly toxic antibiotics derived from strains of the soil bacterium Bacillus polymyxa and used to treat various infections with gram-negative bacteria.
from Wiktionary, Creative Commons Attribution/Share-Alike License
- n. Any of several toxic antibiotics, derived from the soil bacterium Bacillus polymyxa, used to treat infections by gram-negative bacteria
from WordNet 3.0 Copyright 2006 by Princeton University. All rights reserved.
- n. any of several toxic antibiotics obtained from a particular soil bacterium
Antibiotics used during vaccine manufacture include neomycin, polymyxin B, streptomycin and gentamicin.
A good ointment is one that contains a neomycin/polymyxin combination (for example Neosporin or Polysporin).
In this study, the genetic determinants for capsular polysaccharide level and lipopolysaccharide modification involved in polymyxin B resistance of the opportunistic pathogen Klebsiella pneumoniae were characterized.
The cationic peptide antibiotic polymyxin has recently been reevaluated in the treatment of severe infections caused by gram negative bacteria.
Deletion of the rcsB, which encoded an activator for the production of capsular polysaccharide, had a minor effect on K. pneumoniae resistance to polymyxin B.
The study reports a role of the capsular polysaccharide level and the pmr genes for K. pneumoniae resistance to polymyxin B.
Salmonella, expression of pmrD in K. pneumoniae was dependent on PhoP, the activated PmrD would then bind to PmrA to prolong the phosphorylation state of the PmrA, and eventually turn on the expression of pmr for the resistance to polymyxin B. Conclusions
The PmrD connector-mediated regulation for the expression of pmr genes involved in polymyxin B resistance was also demonstrated by DNA EMSA, two-hybrid analysis and in vitro phosphor-transfer assay.
Salmonella, PhoP in K. pneumoniae plays a major regulatory role in polymyxin B resistance.
The polymyxin B resistance was shown to be regulated by the two-component response regulators PhoP and PmrA at low magnesium and high iron, respectively.
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