Definitions
from The American Heritage® Dictionary of the English Language, 5th Edition.
- noun A genetic element that undergoes replication as an autonomous unit.
from Wiktionary, Creative Commons Attribution/Share-Alike License.
- noun genetics A
DNA molecule or a region of DNA that replicates as an individual unit. A replicon may be, for instance, achromosome , aplasmid or aphage .
Etymologies
from The American Heritage® Dictionary of the English Language, 4th Edition
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Examples
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Tucker and a panel of experts explained that the first medication on trial was the AlphaVax replicon Vector (ArV) clade C
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The trials would assess the AlphaVax replicon Vector (ArV) candidate vaccine, a technology that used artificial virus-like particles containing parts of a strain of Venezuelan equine encephalitis, and a gene from a South African HIV strain, to deliver the vaccine to the immune system.
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This report shows that targeting the HCV replicon system using SOFA-HDV ribozymes was not really productive, even when great attention was devoted towards optimizing their design.
PLoS ONE Alerts: New Articles Michel V. L�vesque et al. 2010
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The cleavage of the HCV (−) strand by all of these SOFA-HDV ribozymes was then accessed using both the replicon and the lentivirus systems as described above.
PLoS ONE Alerts: New Articles Michel V. L�vesque et al. 2010
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The ability of the resulting SOFA-HDV ribozymes to inhibit HCV replication was further examined using a luciferase-based replicon.
PLoS ONE Alerts: New Articles Michel V. L�vesque et al. 2010
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From that point and until the end of the experiment, Huh-7 cells containing the replicon were never in contact with media containing G-418 or antibiotic.
PLoS ONE Alerts: New Articles Michel V. L�vesque et al. 2010
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The potential abilites of all SOFA-HDV ribozymes to inhibit an HCV replicon were tested.
PLoS ONE Alerts: New Articles Michel V. L�vesque et al. 2010
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Randall G, Grakoui A, Rice CM (2003) Clearance of replicating hepatitis C virus replicon RNAs in cell culture by small interfering RNAs.
PLoS ONE Alerts: New Articles Michel V. L�vesque et al. 2010
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The use of different lentivirus concentrations did not result in improved inhibition of the replicon.
PLoS ONE Alerts: New Articles Michel V. L�vesque et al. 2010
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One potential explanation for the limited cleavage activity might be the bicistronic replicon system used to screen the ribozyme in cellulo, although it has been used successfully in many studies
PLoS ONE Alerts: New Articles Michel V. L�vesque et al. 2010
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