from The American Heritage® Dictionary of the English Language, 4th Edition
- n. An immature red blood cell that contains a network of basophilic filaments.
from Wiktionary, Creative Commons Attribution/Share-Alike License
- n. An immature red blood cell, having a reticular network of RNA
from WordNet 3.0 Copyright 2006 by Princeton University. All rights reserved.
- n. an immature red blood cell containing a network of filaments or granules
We assumed that the same mechanism that is involved in differentiation and maturation of the reticulocyte is also involved in the removal of "naturally occurring" mutant abnormal hemoglobins that are synthesized in different hemoglobinopathies, such as thalassemias and sickle cell anemia, and also in the destruction of the amino acid analogs
The progenitor cell loses its nucleus, and most of its intracellular membranes are degraded; the now non-nucleated form of the cell, termed a reticulocyte, then loses its ribosomes, thus preventing any further synthesis of haemoglobin.
A later stage of the cell known as a reticulocyte, is what finally develops into an erythrocyte.
The model system that was chosen to study proteolysis was degradation of abnormal hemoglobin in the reticulocyte which is the terminally differentiating red blood cell.
"precursor" cell called a reticulocyte, the cell ejects many structures, such as mitochodria and the nucleus (the sac that contains the cell's genes).
"I look for unusual fluctuations," he says, "and the reticulocyte count and OFF-Score are reliable models of that."
What a researcher like Dr. Ashenden looks for, then, is not perfect symmetry or even values that are one-time abnormalities (such as Mr. Millar's initial reticulocyte result) but patterns.
The reticulocyte count in the tests looks at how far away from that figure a rider is.
Mr. Millar's ACE results, including his high initial reticulocyte count, would require further explanation for Dr. Ashenden to make a determination, but his UCI results from the same time period, said Dr. Ashenden, show no sign of doping.
Thus, this important piece of information - the existence of a non-lysosomal proteolytic system, made the choice of the reticulocyte an obvious one.
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