from Wiktionary, Creative Commons Attribution/Share-Alike License
- n. A complex of proteins, first identified in yeast, which plays an important role in recycling transmembrane receptors from endosomes to the trans-Golgi network.
Sorry, no etymologies found.
One such partner was found to be VPS35, a component of a structure called the retromer complex.
Tattersall D, Seaman MN (2007) EHD1 interacts with retromer to stabilize SNX1 tubules and facilitate endosome-to-Golgi retrieval.
From the many genetic screening tests that have been done in yeast, researchers knew that flaws in the retromer complex can cause cells to be vulnerable to rapamycin, just as excess GOLPH3 can.
Chin's team theorized that mammalian GOLPH3 also works with the retromer complex to control the activity of TOR in mammal cells (where it's known at mTOR).
This suggested that the retromer complex in yeast is important for chemical signals sent to and from TOR.
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