thapsigargin

To confirm that mTORC1 regulates JNK / c-Jun activation in response to ER stress, we studied the effect of thapsigargin, which is an ER stressor, and that of anisomycin, which activates JNK in an ER stress-independent manner.

PLoS ONE Alerts: New Articles Etti Bachar et al. 2009

Research on interaction of thapsigargin and certain cell membranes.

USATODAY.com - 2004 All-USA College Academic Third Team 2004

Cells exposed to GSM RF fields at 1 of 7 SARs (0.012, 0.062, 0.125, 0.25, 0.5, 1 or 2 W/kg) for 30 minutes had similar peak thapsigargin-evoked Ca

PLoS ONE Alerts: New Articles Rodney P. O'Connor et al. 2010

* Design and synthesis of SERCA inhibitors base don the pharmacophore of thapsigargin.

Naturejobs - All Jobs 2010

Addition of extracellular Ca2+ to thapsigargin-treated coverslides induced a large store-operated Ca

PLoS ONE Alerts: New Articles Rodney P. O'Connor et al. 2010

This is due to loss of the finite Ca2+ content within the ER and the progressive removal of the ion by plasma membrane ATPases that are insensitive to thapsigargin.

PLoS ONE Alerts: New Articles Rodney P. O'Connor et al. 2010

Co-treatment of the γ-secretase reporter cells with PBA blocked the repressive effects of tunicamycin and thapsigargin upon APP proteolysis, UPR activation, and apoptosis.

Elites TV PLoS ONE 2010

* Design and synthesis of SERCA inhibitors base don the pharmacophore of thapsigargin.

Naturejobs - All Jobs 2010

Three unrelated pharmacological agents (tunicamycin, thapsigargin and brefeldin A) all repressed APP proteolysis in parallel with activation of unfolded protein response (UPR) signaling-a biochemical marker of ER stress.

Elites TV PLoS ONE 2010

* Design and synthesis of SERCA inhibitors base don the pharmacophore of thapsigargin.

Naturejobs - All Jobs 2010