Definitions
Wiktionary
- n. biochemistry A sesquiterpene lactone that is an inhibitor of a certain class of enzymes
Examples
“To confirm that mTORC1 regulates JNK / c-Jun activation in response to ER stress, we studied the effect of thapsigargin, which is an ER stressor, and that of anisomycin, which activates JNK in an ER stress-independent manner.”
“Research on interaction of thapsigargin and certain cell membranes.”
“Three unrelated pharmacological agents (tunicamycin, thapsigargin and brefeldin A) all repressed APP proteolysis in parallel with activation of unfolded protein response (UPR) signaling-a biochemical marker of ER stress.”
“Co-treatment of the γ-secretase reporter cells with PBA blocked the repressive effects of tunicamycin and thapsigargin upon APP proteolysis, UPR activation, and apoptosis.”
“* Design and synthesis of SERCA inhibitors base don the pharmacophore of thapsigargin.”
“This is due to loss of the finite Ca2+ content within the ER and the progressive removal of the ion by plasma membrane ATPases that are insensitive to thapsigargin.”
“Cells exposed to GSM RF fields at 1 of 7 SARs (0.012, 0.062, 0.125, 0.25, 0.5, 1 or 2 W/kg) for 30 minutes had similar peak thapsigargin-evoked Ca”
“Addition of extracellular Ca2+ to thapsigargin-treated coverslides induced a large store-operated Ca”
“There were no significant differences in the time constants for the recovery of thapsigargin-evoked Ca”
“Bii, RF exposure at a wide range of SARs showed no influence on the thapsigargin-induced peak Ca”
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