from Wiktionary, Creative Commons Attribution/Share-Alike License
- n. The actions and interactions of an exogenous compound within an organism, including the compound's affects on processes at the organ, cellular, and molecular levels.
The potency of a chemical, or how toxic it is, depends upon its movement through the body to the target site (toxicokinetics); its ability to interact with the body to cause harm (toxicodynamics); and the dose the body receives (exposure level), which is in turn modified by the toxicokinetics and toxicodynamics of the chemical.
The underlying idea is that the body’s own chemicals (often referred to as endogenous chemicals) can and do affect the kinetics, toxicokinetics and toxicodynamics of chemicals that are foreign to the body (that is, xenobiotics.
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