Definitions
from The American Heritage® Dictionary of the English Language, 5th Edition.
- transitive verb To stimulate the transcription of (a gene in a host cell) by binding to DNA. Genes can be transactivated naturally by a virus or cellular protein or artificially by the insertion of a transactivator gene and segment of DNA into a cell.
from Wiktionary, Creative Commons Attribution/Share-Alike License.
- verb To make a
host cell replicate thegenetic components of avirus
Etymologies
from Wiktionary, Creative Commons Attribution/Share-Alike License
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Examples
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To demonstrate that E2Fs can directly transactivate the Beclin 1 promoter, we performed Beclin 1 promoter reporter assay in T98G cells.
PLoS ONE Alerts: New Articles Bing Wang et al. 2010
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We also show the expression of Beclin 1 depends on E2F, and E2F can transactivate the
PLoS ONE Alerts: New Articles Bing Wang et al. 2010
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Once ligand-bound, the AhR is then able to transactivate the expression of the CYP1A1-controlled PPARβ/δ transgene in the epidermis via the AhR-responsive DXE/XRE element (shown in fig. 2d).
PLoS ONE Alerts: New Articles Malgorzata Romanowska et al. 2010
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The PPAR subfamily of nuclear hormone receptors also includes PPARα (target of fibrate class lipid lowering drugs) and PPARγ (target of the rosiglitazone-family of anti-diabetes drugs), all of which form heterodimers with the RXRα subunit of retinoid receptors and require binding of ligands in order to bind cognate promoters and transactivate distinct set of target genes.
PLoS ONE Alerts: New Articles Malgorzata Romanowska et al. 2010
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We also show the expression of Beclin 1 depends on E2F, and E2F can transactivate the
PLoS ONE Alerts: New Articles Bing Wang et al. 2010
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The molecular function of Tbx1 is unclear although it can transactivate reporters with T-box binding elements.
Elites TV 2009
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Our analysis of the functional activity of p63 on the ZEB1 promoter showed that both the TAβ and ΔNβ isoforms could bind to and transactivate through their cognate site in the ZEB1 promoter.
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(B) Specific p63 isoforms can transactivate the ZEB1 promoter.
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The number of distinct signaling pathways that can transactivate the epidermal growth factor receptor (EGFR) in a single cell type is unclear.
Journal of Biological Chemistry current issue K. D. Rodland 2008
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To test if p63 still remains able to transactivate in these unresponsive cells, the ES-derived ectodermal cell line was cotransfected with ΔNp63 and a p63-responsive reporter construct
PLoS ONE Alerts: New Articles Alain Medawar et al. 2008
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