Definitions

from Wiktionary, Creative Commons Attribution/Share-Alike License

  • n. A pyridylallylamine, the first selective serotonin reuptake inhibitor antidepressant to be marketed, developed in the early 1980s and later banned due to serious neuropathy and hypersensitivity reactions.

Etymologies

Sorry, no etymologies found.

Examples

  • Some six years later, S. B. Ross and associates found a powerful member of this class of substances called zimelidine.

    Alcohol and The Addictive Brain

  • But in the meantime, Astra, spurred on by Carlsson, was taking zimelidine through clinical trials in Sweden.

    MANUFACTURING DEPRESSION

  • Carlsson knew better because he had invented the first SSRI, zimelidine, which the Swedish pharmaceutical company Astra brought to market as an antidepressant named Zelmid in 1982, five years before Prozac.

    MANUFACTURING DEPRESSION

  • By 1971, he and his team had come up with zimelidine Zelmid, the first drug designed specifically to inhibit serotonin reuptake.

    MANUFACTURING DEPRESSION

  • But in 1983, just as the process was getting under way, trouble arose in Europe: zimelidine syndrome, a flu-like condition, and, more ominously, an outbreak of Guillain-BarrĂ© syndrome, a sometimes fatal neurological disorder, among users.

    MANUFACTURING DEPRESSION

  • Although zimelidine appears to have possible applications as an anticraving agent, its side effects pose serious problems.

    Alcohol and The Addictive Brain

  • The first is that zimelidine acts in the brain to reduce craving.

    Alcohol and The Addictive Brain

  • Later, Naranjo would find a drug called citralopam that also increases the availability of serotonin at the synapse and reduces craving, with fewer side effects than zimelidine.

    Alcohol and The Addictive Brain

  • Those who took zimelidine showed a small decrease in alcohol consumption, but a marked increase in the number of days of complete abstinence.

    Alcohol and The Addictive Brain

  • To explore zimelidine further, Claudio Naranjo and associates at the University of Toronto set up an experiment involving 13 human subjects who were all alcoholics.

    Alcohol and The Addictive Brain

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