Definitions
from Wiktionary, Creative Commons Attribution/Share-Alike License.
- abbreviation sciences The concentration of an
inhibitor that is required for 50-percentinhibition of anenzyme in vitro .
Etymologies
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Examples
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The dashed black lines mark the IC50 which is aorund 130 µg/ml after pre-incubation. doi: 10.1371/journal. pone.0008682.g002
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The dashed black lines mark the IC50 which is aorund 130 µg/ml after pre-incubation. doi: 10.1371/journal. pone.0008682.g002
PLoS ONE Alerts: New Articles Janina K. Hellmann et al. 2010
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Antimalarial activities are given in IC50 values and these have been categorized as follows:
Chapter 7 1991
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Perifosine IC50 is between 0.6-8.9 μM and Perifosine structure shows that it is a synthetic alkylphospholipid derivative.
unknown title 2011
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In addition, reported that a CRN-substituted microRNA antagonist demonstrated increased potency with an approximate 60-fold improvement in the IC50.
unknown title 2011
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Antibody/Receptor IC50 (nM) SD mIL-10 19.5 Rat × hIL-10 mAb 37.9 17.8 JES3. 12G8 Cyno IL-10
FreshPatents.com: Notable Patent Applications - 07/22/2010 2010
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To plot the data and calculate IC50 the GraphPad Prism Software was used.
FreshPatents.com: Notable Patent Applications - 07/22/2010 2010
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Further studies revealed an ATP competitive mode of action and the potent inhibition of the cellular downstream target Rsk1 in tumor cells with an IC50 value of 158nM.
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Drug concentrations were selected according to half maximal inhibitory concentration (IC50), known for most compounds.
PLoS ONE Alerts: New Articles Ville Härmä et al. 2010
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The IC50 of EO in intestinal mucosal homogenates was 2.2 mg/mL.
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