Niemann-Pick disease

from The American Heritage® Dictionary of the English Language, 5th Edition.

• noun An inherited disorder of lipid metabolism that is characterized by the accumulation of lipids in the spleen and liver and sometimes in the lungs, bone marrow, and brain, and can cause death at a young age. It occurs commonly in infants of Ashkenazic Jewish descent.

from Wiktionary, Creative Commons Attribution/Share-Alike License.

• noun medicine Any of a group of fatal inherited metabolic disorders associated with sphingomyelin accumulation in the central nervous system.