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Examples
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It is possible now to produce a stem cell from almost any other human cell instead of using embryos as needed previously, albeit the risk of tumorigenesis due to c-myc and retroviral gene transfer remains to be determined.
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Among the first such genes to be engineered into a mouse was c-myc, an oncogene discovered in lymphoma cells.
The Emperor of All Maladies Siddhartha Mukherjee 2010
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Among the first such genes to be engineered into a mouse was c-myc, an oncogene discovered in lymphoma cells.
The Emperor of All Maladies Siddhartha Mukherjee 2010
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Sinn et al., “Coexpression of MMTV/v-Ha-ras and MMTV/c-myc Genes in Transgenic Mice: Synergistic Action of Oncogenes in Vivo,” Cell 49, no.
The Emperor of All Maladies Siddhartha Mukherjee 2010
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Among the first such genes to be engineered into a mouse was c-myc, an oncogene discovered in lymphoma cells.
The Emperor of All Maladies Siddhartha Mukherjee 2010
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Sinn et al., “Coexpression of MMTV/v-Ha-ras and MMTV/c-myc Genes in Transgenic Mice: Synergistic Action of Oncogenes in Vivo,” Cell 49, no.
The Emperor of All Maladies Siddhartha Mukherjee 2010
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Sinn et al., “Coexpression of MMTV/v-Ha-ras and MMTV/c-myc Genes in Transgenic Mice: Synergistic Action of Oncogenes in Vivo,” Cell 49, no.
The Emperor of All Maladies Siddhartha Mukherjee 2010
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The technique knocks in four genes using a lentivirus vector using (as far as I can tell) artificial promoters, and one of the genes (c-myc) is a doozy of a cancer gene.
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The issues under discussions: 1. The possible contribution of a virus to the origin to the tumor versus the LINE insertion upstream of c-myc.
You *can* teach an old dog new tricks - The Panda's Thumb 2006
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(Invitrogen), and to fuse the C-termini to a c-myc epitope and 6X-His tags within the vector.
PLoS ONE Alerts: New Articles Neelkamal Chaudhary et al. 2010
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