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- n. Plural form of carbapenemase.
Sorry, no etymologies found.
Similar enzymes in the same class, known as carbapenemases, have been detected worldwide.
Bacteria that produce carbapenemases are often referred to in the news media as "superbugs" because infections caused by them are difficult to treat.
The gene for NDM-1 is one member of a large gene family that encodes beta-lactamase enzymes called carbapenemases.
It overcomes bacterial resistance by several mechanisms and is not easily destroyed by bacterial beta-lactamase enzymes, such as extended-spectrum beta-lactamases (ESBLs), carbapenemases and the recently characterized New Delhi metallo-beta-lactamase 1 (NDM-1), which cause resistance against many currently marketed antibiotics.
Studies will be presented of MK-7655 a developmental beta-lactamase inhibitor that has shown activity against class A and class C carbapenemases, which are increasing in prevalence worldwide and are believed to play a significant role in bacterial resistance.