Definitions
from Wiktionary, Creative Commons Attribution/Share-Alike License.
- noun A
fungal metabolite , having a 3,6-epidithio-diketopiperazine structure, that hasantimicrobial andcytostatic activity
Etymologies
Sorry, no etymologies found.
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Examples
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Several research groups have produced related analogues of chaetocin, but the total synthesis of this molecule has eluded organic chemists since its discovery forty years ago-setting up a significant test to the synthetic skills of Sodeoka and her team.
innovations-report 2010
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Cysteines have a thiol (- SH) side chain that may be able to form transitory bonds with the critical disulfide bridges of chaetocin.
innovations-report 2010
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The researchers believe that further studies into the molecular mechanisms of chaetocin should deliver a new generation of enzyme-specific pharmaceuticals that can control gene expression patterns-an important step in the treatment of cancerous diseases.
innovations-report 2010
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Although both chaetocin isomers showed strong inhibitory activity, the molecule without the sulfur bridges was inactive-demonstrating the critical role of this functionality.
innovations-report 2010
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With the chemical synthesis of chaetocin complete, Sodeoka and colleagues prepared various analogues of the molecule-two optical isomers of chaetocin, and a version missing the disulfide bridges.
innovations-report 2010
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The team was extremely gratified when the final step in the reaction, which involved ten bond-forming and - cleaving events, generated chaetocin with the correct geometrical structure.
innovations-report 2010
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The first total synthesis of the complex natural product chaetocin expands the tools to reverse lethal gene expressions
innovations-report 2010
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Overall, the team's method demonstrates a highly efficient way to produce chaetocin, because the total synthesis required only nine chemical transformations.
innovations-report 2010
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He says, "it is only chaetocin that comes from natural sources."
innovations-report 2010
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M. Total synthesis of (+) - chaetocin and its analogues: Their histone methyltransferase G9a inhibitory activity.
innovations-report 2010
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