Definitions

from Wiktionary, Creative Commons Attribution/Share-Alike License

  • n. A fungal metabolite, having a 3,6-epidithio-diketopiperazine structure, that has antimicrobial and cytostatic activity

Etymologies

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Examples

  • Overall, the team's method demonstrates a highly efficient way to produce chaetocin, because the total synthesis required only nine chemical transformations.

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  • The first total synthesis of the complex natural product chaetocin expands the tools to reverse lethal gene expressions

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  • He says, "it is only chaetocin that comes from natural sources."

    innovations-report

  • The team was extremely gratified when the final step in the reaction, which involved ten bond-forming and - cleaving events, generated chaetocin with the correct geometrical structure.

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  • The researchers believe that further studies into the molecular mechanisms of chaetocin should deliver a new generation of enzyme-specific pharmaceuticals that can control gene expression patterns-an important step in the treatment of cancerous diseases.

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  • With the chemical synthesis of chaetocin complete, Sodeoka and colleagues prepared various analogues of the molecule-two optical isomers of chaetocin, and a version missing the disulfide bridges.

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  • M. Total synthesis of (+) - chaetocin and its analogues: Their histone methyltransferase G9a inhibitory activity.

    innovations-report

  • Although both chaetocin isomers showed strong inhibitory activity, the molecule without the sulfur bridges was inactive-demonstrating the critical role of this functionality.

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  • Several research groups have produced related analogues of chaetocin, but the total synthesis of this molecule has eluded organic chemists since its discovery forty years ago-setting up a significant test to the synthetic skills of Sodeoka and her team.

    innovations-report

  • Cysteines have a thiol (- SH) side chain that may be able to form transitory bonds with the critical disulfide bridges of chaetocin.

    innovations-report

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