Definitions
from Wiktionary, Creative Commons Attribution/Share-Alike License.
- noun biochemistry The conversion of
glutamine ,asparagine ,glutamine residues in apolypeptide toglutamic acid oraspartic acid by treatment with strongacid , transamidase or deamidase. - noun organic chemistry Conversion of an
amide to acarboxylic acid .
Etymologies
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Examples
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However, in the more alkaline environment (higher pH) a chemical process called deamidation converts Bcl-xL into a form that allows cells with damaged DNA to die.
innovations-report 2009
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This is the first demonstration of a role for deamidation in human malignancy.
innovations-report 2009
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The therapeutic interest in this research comes from the authors 'finding that simply switching back on the Bcl-xL deamidation pathway causes the cancer cells to die.
innovations-report 2009
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So drug resistance can be overcome by activating the NHE-1 pathway, thereby increasing the pH inside the cell, and in turn Bcl-xL deamidation and apoptosis.
innovations-report 2009
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As expected, Imatinib was unable to restore the Bcl-xL deamidation pathway in the patient's cells.
innovations-report 2009
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The authors have discovered that it is these kinases that block the key Bcl-xL deamidation pathway that normally allows DNA damaged cells to die.
innovations-report 2009
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Stretching this analogy further, it is also possible to suggest that Asn and Gln can be arginylated with or without deamidation, that lysine (Lys) can accept Arg onto its side chain amino group, and that serine, threonine, and Cys can be arginylated on the side chains after oxidation.
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Stretching this analogy further, it is also possible to suggest that Asn and Gln can be arginylated with or without deamidation, that lysine (Lys) can accept Arg onto its side chain amino group, and that serine, threonine, and Cys can be arginylated on the side chains after oxidation.
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Stretching this analogy further, it is also possible to suggest that Asn and Gln can be arginylated with or without deamidation, that lysine (Lys) can accept Arg onto its side chain amino group, and that serine, threonine, and Cys can be arginylated on the side chains after oxidation.
-
Stretching this analogy further, it is also possible to suggest that Asn and Gln can be arginylated with or without deamidation, that lysine (Lys) can accept Arg onto its side chain amino group, and that serine, threonine, and Cys can be arginylated on the side chains after oxidation.
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