from Wiktionary, Creative Commons Attribution/Share-Alike License
- n. The removal of palmitate esters bound to a protein
Sorry, no etymologies found.
The inhibitor, palmostatin B, perturbs the cellular acylation cycle at the level of depalmitoylation and thereby causes a loss of the precise steady-state localization of palmitoylated Ras.
Cycles of depalmitoylation and repalmitoylation critically control the steady-state localization and function of various peripheral membrane proteins, such as Ras proto-oncogene products.
Figure 2: Palmostatin B specifically inhibits depalmitoylation.
In first half of 2009 Santaris Pharma and academic partners published an article titled: A functional screen implicates microRNA-138-dependent regulation of the depalmitoylation enzyme APT1 in dendritic spine morphogenesis.