Definitions

from Wiktionary, Creative Commons Attribution/Share-Alike License

  • n. Plural form of heterodimer.

Etymologies

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Examples

  • Fra-1 forms activator protein-1 heterodimers with Jun partners and drives gene transcription.

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  • This cell-based assay technology identifies molecules acting through pairs of different GPCRs, known as GPCR heterodimers.

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  • Microtubules are dynamic structures composed of α-β-tubulin heterodimers that are essential in cell division and are important targets for cancer drugs.

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  • The PPAR subfamily of nuclear hormone receptors also includes PPARα (target of fibrate class lipid lowering drugs) and PPARγ (target of the rosiglitazone-family of anti-diabetes drugs), all of which form heterodimers with the RXRα subunit of retinoid receptors and require binding of ligands in order to bind cognate promoters and transactivate distinct set of target genes.

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  • It could also be seen that the size of the complex formed with U937 nuclear extract was lower as compared to that formed with nuclear extract from 293T cells over - expressing c-Rel probably pointing to the formation of P65 c-Rel homodimers in the case of 293T cells over-expressing c-Rel as compared to the formation of P50/P65-c-Rel heterodimers in U937 cells.

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  • NKG2A is an inhibitory NK receptor that has been reported to form disulfide-linked heterodimers with invariant CD94.

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  • In particular, in silico docking analysis showed that GD3 has a high affinity for the pore formed by four tubulin heterodimers (type I pore), thus suggesting a possible interaction between tubulin and GD3.

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  • Three major inhibitory NK receptors are found on peripheral as well as on decidual NK cells: the CD94/NKG2 heterodimers which recognize the HLA-E molecule loaded with MHC class I signal peptide

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  • These proteins interact with each other and assemble as non-covalent heterodimers and their TMs play a major role in heterodimer formation, membrane anchoring and endoplasmic reticulum retention

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  • Interestingly, both β-arrestin 1 and β-arrestin 2 are required to promote the activation of Akt. The requirement of both proteins might be indicative of a need to form heterodimers to activate the β-arrestin-dependent signaling pathway as it was described for MAPK activation

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