minichromosome

At the same time, Jack Szostak had made the observation that a linear DNA molecule, a type of minichromosome, is rapidly degraded when introduced into yeast cells.

The 2009 Nobel Prize in Physiology or Medicine - Press Release 2009

Furthermore, we hypothesize that the initiators in this model correspond to loaded minichromosome maintenance complexes.

Naturejobs - All Jobs Scott Cheng-Hsin Yang 2010

The details of this model support a specific molecular mechanism for the regulation of replication timing, in which the number of minichromosome maintenance (MCM) complexes loaded at an origin regulates, in part, the origin firing time.

Naturejobs - All Jobs Scott Cheng-Hsin Yang 2010

(P160) 1a minichromosome maintenance protein 7 205 MYBBP1A homolog isoform MCM7 NP_032594. 1 5 1094 15 2 16 4 1294 1.09E-0422

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± ± 0.62 Customers 89 1 3 MAP1B NP_032660. 1 79 1 118 0.30 3.37 NDUFA4 NP_035016. 1 NADH dehydrogenase (ubiquinone) 1 MCM5 NP_032592. 1 3 minichromosome maintenance deficient 5, cell76ivision cycle 46 15 MAPK3 NP_036082. 1 mitogen activated protein kinase 8473 1 1 4 15 128 1.21E-032

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±1 5.85E-04 2 1.63E-04 0.88 ± ± 0.09 4 364 8 80 1 76 0.28 NP_001008705. 1 B UD31 homolog (yeast) MCM6 NP_032593. 1 (includes EG: 231 889) BUD31 minichromosome maintenanceproteinLZTFL1 NP_201579. 1 leucine zipper transcription factor-like 1 283 76300 1 5 18 11 79 4.13E-041

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MCM4 NP_032591. 2 MARCKSL1 NP_034937. 1 proteinLRRC40 protein minichromosome maintenance MARCKS-like NP_077156. 2 leucine rich repeat containing 40 12 181338 3 6 39 8 88 1.66E-041

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Stillman B (2000) Chromatin association of human origin recognition complex, cdc6, and minichromosome maintenance proteins during the cell cycle: Assembly of prereplication complexes in late mitosis.

PLoS ONE Alerts: New Articles Anaïs Estrada-Gelonch et al. 2009