Definitions

from Wiktionary, Creative Commons Attribution/Share-Alike License.

  • adjective Pertaining to a neural connection between the substantia nigra and the striatum.

Etymologies

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Examples

  • When GDNF flooded a bundle of nerves known as the nigrostriatal tract, a potential target for Parkinson therapy, the obese rats lost a great deal of weight - about 80 grams.

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  • When GDNF flooded the nerve bundle known as the nigrostriatal tract, a potential target for Parkinson therapy, the obese rats lost a great deal of weight.

    news | GS | http://www.gainesville.com

  • "The results show for the first time that GDNF overexpression in an anatomical area in the brain known as the nigrostriatal tract is involved in metabolism," Mandel said.

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  • Once within brain, neurons producing certain neurotransmitters, such as dopaminergic nigrostriatal cells, the excess phenylalanine can inhibit enzymes (like tyrosine hydroxylase) needed to synthesize the neurotransmitters.

    Santa Fe Pediatrician Regales Hawaii Legislative Committee with Dangers of Aspartame

  • Parkinson's disease is known to occur when dopamine neurons die in the brain's nigrostriatal pathway.

    Mind Hacks: Brains needed!

  • Parkinson's disease is known to occur when dopamine neurons die in the brain's nigrostriatal pathway.

    Mind Hacks: October 2005 Archives

  • Nrf2-knockout mice showed exacerbated gliosis and dopaminergic nigrostriatal degeneration, as determined by immunohistochemical staining of tyrosine hydroxylase in striatum (STR) and substantia nigra (SN) and by HPLC determination of striatal dopamine and 3,4 - dihydroxyphenylacetic acid (DOPAC).

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  • Nrf2-knockout mice showed exacerbated gliosis and dopaminergic nigrostriatal degeneration, as determined by immunohistochemical staining of tyrosine hydroxylase in striatum (STR) and substantia nigra

    PLoS ONE Alerts: New Articles

  • Perez FA, Scouras AD, Stoll EA, Gale SD, et al. (2006) Cre recombinase-mediated restoration of nigrostriatal dopamine in dopamine-deficient mice reverses hypophagia and bradykinesia.

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  • These evidences have led to the speculation that increased HO-1 levels might be the main responsible for the accumulation of free iron and subsequent damage to the nigrostriatal system

    PLoS ONE Alerts: New Articles

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