Definitions
from Wiktionary, Creative Commons Attribution/Share-Alike License.
- adjective Not
polymorphic .
Etymologies
from Wiktionary, Creative Commons Attribution/Share-Alike License
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Examples
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In both panels blue bars represent the steady state expression levels assayed at locus 1 (polymorphic), while red bars represent steady state expression levels assayed at locus 2 (nonpolymorphic).
PLoS ONE Alerts: New Articles Arne B. Gjuvsland et al. 2010
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In all four cases we monitored the gene expression from both the polymorphic and the nonpolymorphic locus.
PLoS ONE Alerts: New Articles Arne B. Gjuvsland et al. 2010
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A62V is an accessory NRTI-resistance mutation which is nonpolymorphic except for its presence in 16\% of subtype A viruses due to a founder effect within the intravenous drug user epidemic in Eastern Europe
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The number of sequences from ARV-naïve persons infected with subtype B and non-B HIV-1 viruses in our analysis dataset has approximately doubled since the 2007 publication, increasing the confidence with which nonpolymorphic mutations can be identified.
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Identification of nonpolymorphic mutations and mutations not occurring at highly polymorphic positions
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Although we selected only nonpolymorphic drug-resistance mutations - defined as those occurring at a prevalence ≤ 0. 5\% in untreated individuals in subtypes for which >
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For the purposes of generating a nonpolymorphic list of drug resistance mutations, we defined nonpolymorphic mutations to be mutations present at a frequency ≤ 0. 5\% in ARV-naïve individuals infected with subtypes for which >
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Six nonpolymorphic NRTI-resistance mutations including E44A, D67E, T69N, K70E, L74I, and K219N were not present on the 2007 SDRM list.
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The allele interaction sign motifs of the nonpolymorphic locus are the same as for the polymorphic one (
PLoS ONE Alerts: New Articles Arne B. Gjuvsland et al. 2010
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In the positive feedback case two positive actions create the same sign motifs as for positive autoregulation for the polymorphic and the nonpolymorphic locus (
PLoS ONE Alerts: New Articles Arne B. Gjuvsland et al. 2010
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