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- n. An opiate analogue, the N-demethylated derivative of morphine.
The result was that “X” was blocked, but normorphine was unaffected.
In a test of his hypothesis, he found that the narcotic antagonist naloxone, applied either before or after the addition of “X” or normorphine, blocked or reversed the inhibitory action of both compounds.
With these measurements as a baseline, he applied normorphine to the tissues, and found that this morphine-like material reduced the intensity of the contractions, as expected.
This indicated that “X” is a peptide, and that normorphine is not a peptide.
About half of the material was converted into opiate compounds such as normorphine, morphine, norcodeine, and codeine.
After the opiate effect wore off, Hughes applied a small amount of “X” to the vas deferens tissues, and found that this natural compound was a much more powerful inhibitor of muscular contraction than normorphine had been.