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- n. Plural form of sialidase.
Sorry, no etymologies found.
This enzyme is specific for polysialic acid and is a member of a family of endo-sialidases.
The results obtained in this work, showing that different recombinant TcTS protein products are inhibited to different extents by the four VHHs tested, indicate that VHHs could recognize minor antigenic differences present in the polymorphic population of natural trans-sialidases, as this enzymatic activity potentially derives from the simultaneous expression of about 70 different genes
The simultaneous expression of a large number of trans-sialidases slightly differing in primary sequence but not in enzymatic activity might delay the complete inhibition of the parasite enzyme.
Cremona ML, Amaya MF, Buschiazzo A, Giambiagi S, et al. (2001) Probing molecular function of trypanosomal sialidases: single point mutations can change substrate specificity and increase hydrolytic activity.
Analysis of individual recombinant trans-sialidases showed that enzymes expressed from different genes were inhibited to different extents (from 8 to 98\%) by the llama antibodies.
Purified VHHs inhibited recombinant TcTS611 / 2 by 60-80\% and VHHS114 inhibited 8-98\% the enzymatic activity of different recombinant trans-sialidases.