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- v. To induce immunological tolerance
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Animal models have shown that allogeneic hematopoietic stem-cell transplantation can lead to remission of experimental autoimmune disease that is attributed to a "graft-versus-autoimmunity" effect,1 wherein donor hematopoietic and immune cells apparently tolerize autoreactive recipient T cells and B cells.
BHT-3009 is an antigen-specific plasmid encoding myelin basic protein (MBP) that aims to reprogram the immune system to tolerize to, rather than attack, myelin antigens in the central nervous systems of multiple sclerosis (MS) patients.
Clinical results to date suggest that BHT-3009 reprograms the immune system to tolerize to, rather than attack, the myelin antigens in the central nervous system of MS patients.
Solimena M, Flavell RA, Sherwin RS, Hayday AC (1998) Widespread expression of an autoantigen-GAD65 transgene does not tolerize non-obese diabetic mice and can exacerbate disease.
So it's quite striking that TSCOT-positive cortical epithelial cells can tolerize the entire T cell repertoire, even when that repertoire is vastly skewed toward self-reactivity.