Definitions

from Wiktionary, Creative Commons Attribution/Share-Alike License

  • n. A complex of proteins associated with the translocation of nascent polypeptides into the interior space of the endoplasmic reticulum from the cytosol

Etymologies

Sorry, no etymologies found.

Examples

  • SRP-ribosome complex then docks to the SRP-receptor and channel ( "translocon").

    The Nobel Prize in Physiology or Medicine 1999

  • Hiyoshi H, Gotoh K, Akeda Y, Matsuda S, et al. (2008) Identification of two translocon proteins of Vibrio parahaemolyticus type III secretion system 2.

    PLoS ONE Alerts: New Articles

  • Angelini S, Deitermann S, Koch HG (2005) FtsY, the bacterial signal-recognition particle receptor, interacts functionally and physically with the SecYEG translocon.

    PLoS ONE Alerts: New Articles

  • There is growing evidence of direct interaction between the SR and the translocon at the membrane in both bacterial and eukaryotic systems In contrast to their eukaryotic homologues, which are heterodimers containing a separate membrane anchoring subunit bacterial and archaeal receptors are composed of just the SR core protein, FtsY.

    PLoS ONE Alerts: New Articles

  • At the membrane, upon reciprocal GTP hydrolysis the SRP•SR complex dissociates triggering transfer of the ribosome-nascent chain to the translocon.

    PLoS ONE Alerts: New Articles

  • In Pfu-FtsY, the N-terminus of helix αN1 is positively charged and could constitute the primary membrane interaction site supporting initial attachment of the targeting complex to the membrane and / or interaction with the membrane-embedded translocon.

    PLoS ONE Alerts: New Articles

  • Cheng Z, Mandon EC, Gilmore R (2008) An interaction between the SRP receptor and the translocon is critical during cotranslational protein translocation.

    PLoS ONE Alerts: New Articles

  • These "short" receptors, nevertheless, efficiently target the ribosome-nascent chain-SRP complex to the translocon, raising the question of what are the structural determinants for the membrane interaction.

    PLoS ONE Alerts: New Articles

  • The αN1 helix of the receptor is freely accessible to promote interactions with the membrane and / or the translocon, while the equivalent region in SRP54 is not accessible because of its vicinity with the SRP RNA.

    PLoS ONE Alerts: New Articles

  • [30], interaction with the translocon, and possibly regulation of the GTPase cycle.

    PLoS ONE Alerts: New Articles

Comments

Log in or sign up to get involved in the conversation. It's quick and easy.