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Examples
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Stress and inflammation produce derivatives of cortisol and cholesterol, which trigger misfolding in A-beta proteins.
Connecting the Pieces of the Alzheimer's Puzzle Matt Ridley 2011
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Stress and inflammation produce derivatives of cortisol and cholesterol, which trigger misfolding in A-beta proteins.
Connecting the Pieces of the Alzheimer's Puzzle Matt Ridley 2011
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Which brings us to piece 5, this week's announcement of the discovery by Jeffery Kelly and his colleagues at the Scripps Research Institute that a chemical formed when cholesterol reacts with ozone attaches to A-beta and makes the misfolding of it more likely.
Connecting the Pieces of the Alzheimer's Puzzle Matt Ridley 2011
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This research will look at how clots or bleeds in the smallest blood vessels in the brain could seed the accumulation of A-beta proteins, an indication of plaque in the brain which often occurs in Alzheimer's patients.
L'Oreal-UNESCO USA Fellowships Awarded Peggy 2009
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Piece 1 is the immediate cause of Alzheimer's disease: the appearance of insoluble "plaques" made of a small protein called amyloid beta A-beta for short inside brain cells.
Connecting the Pieces of the Alzheimer's Puzzle Matt Ridley 2011
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Chris Dobson of Cambridge University made 17 slight genetic adjustments to the A-beta protein to make it either more or less soluble.
Connecting the Pieces of the Alzheimer's Puzzle Matt Ridley 2011
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Cortisol, too, is beginning to look like an accomplice in the misfolding of A-beta, according to work at the University of California at Irvine.
Connecting the Pieces of the Alzheimer's Puzzle Matt Ridley 2011
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Research published last month by scientists at Brown University revealed that both parts of this mechanism—the detector and the refolder—are working, but overwhelmed, in diseased brains; they can't keep up with the workload of too many misfolded A-beta proteins.
Connecting the Pieces of the Alzheimer's Puzzle Matt Ridley 2011
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But our study suggests that this activity may actually be a primary effect of A-beta and an early determinant of cognitive failure.
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In the new study, Gladstone scientists found A-beta triggers abnormal over-excitation of the same brain networks that are responsible for learning and memory.
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