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Examples
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A biomedical research company in Belgium, called Ablynx, has been working on developing drugs based on antibodies found in camels and llamas, called nanobodies.
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Ablynx is probably closest to putting a product on the market -- a drug to prevent blood clots that tend to form in patients who have had stents implanted to open a blocked artery.
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Ablynx is developing 24 different antibody-based drugs, all using llamas, Mr. Moses said.
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Ablynx tries to keep their stress levels down so their immune systems produce the required antibodies.
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Ablynx uses llamas rather than camels because they are cheaper and easier to buy in Europe, where people tend to keep them as pets.
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Wyeth is hoping the Ablynx drug will help replace its blockbuster arthritis treatment, Enbrel, when the drug's patent expires after 2011.
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A major problem is that it sounds too good to be true, said Serge Muyldermans, director of the Cellular and Molecular Immunology lab at the Vrije Universiteit in Brussels and one of the founders of Ablynx, the Belgian biotech firm that has the patents on using llama and camel antibodies.
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If the drug passes all its clinical trials, it could be on the market in 2012 or 2013, said Ablynx Chief Executive Edwin Moses
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Ablynx -- which calls its llama antibodies "nanobodies" -- also has a partnership with Wyeth to develop a new arthritis drug that will use nanobodies to block TNF alpha, an immune-system protein that causes the inflammation characteristic of rheumatoid arthritis.
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Having received this accreditation, Ablynx's GMP unit will now perform release-testing on Drug Substance and Drug Product batches and independently perform all stability studies on these batches.
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