Angiogenic

This report part extensively analyses 108 identified targets of angiogenesis drugs, organized into 88 drug target strategies, and assesses them in 44 different cancer indications This part is based on the following publication: Target Atlas: Competitive Insights to Anti-Angiogenic Drug R&D in

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Angiogenic masters: PMAP www. proteolysis.org matrix metalloproteinases (MMPs) are the invisible modelers of the blood vessel formation.

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Angiogenic factors were detected in three tissue microarrays comprising normal liver, paired tumor tissue (TT) and AT from 105 patients (who had undergone hepatectomy for HCC) using immunohistochemistry.

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Yonemitsu Y, Yamashita A, Sata S, Tanii M, et al. (2002) Angiogenic gene therapy for experimental critical limb ischemia: acceleration of limb loss by overexpression of vascular endothelial growth factor 165 but not of fibroblast growth factor-2.

PLoS ONE Alerts: New Articles Koji Taniguchi et al. 2009

Kleiman and Califf 2000 FIRST multicenter study • n = 337 total in 3: 1 ratio of active agent to placebo • Randomized: Yes • Angiogenic Factor: FGF-2 • Administration Route: Intracoronary

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Rosengart et al. 1999 n = 21 • Randomized: No • Angiogenic Factor: VEGF121 viral vector • •

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Cao R, Hedlund E-M, Wang Z, Zhao X, et al. (2007) Angiogenic factors FGF2 and PDGF-BB synergistically promote murine tumor neovascularisation and metastasis.

PLoS ONE Alerts: New Articles Tania Maffucci et al. 2009

Oocyte-Specific Deletion of Pten in Mice Reveals a Stage-Specific Function of PTEN/PI3K Signaling in Oocytes in Controlling Follicular Activation Combined Anti-Angiogenic Therapy Targeting PDGF and VEGF Receptors Lowers the Interstitial Fluid Pressure in a Murine Experimental Carcinoma PAR6, A Potential Marker for the Germ Cells Selected to Form Primordial Follicles in Mouse Ovary Enhancing Survival of Mouse Oocytes Following Chemotherapy or Aging by Targeting Bax and Rad51

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Oocyte-Specific Deletion of Pten in Mice Reveals a Stage-Specific Function of PTEN/PI3K Signaling in Oocytes in Controlling Follicular Activation Combined Anti-Angiogenic Therapy Targeting PDGF and VEGF Receptors Lowers the Interstitial Fluid Pressure in a Murine Experimental Carcinoma PAR6, A Potential Marker for the Germ Cells Selected to Form Primordial Follicles in Mouse Ovary Enhancing Survival of Mouse Oocytes Following Chemotherapy or Aging by Targeting Bax and Rad51

Elites TV PLoS ONE 2010

Oocyte-Specific Deletion of Pten in Mice Reveals a Stage-Specific Function of PTEN/PI3K Signaling in Oocytes in Controlling Follicular Activation Combined Anti-Angiogenic Therapy Targeting PDGF and VEGF Receptors Lowers the Interstitial Fluid Pressure in a Murine Experimental Carcinoma PAR6, A Potential Marker for the Germ Cells Selected to Form Primordial Follicles in Mouse Ovary Enhancing Survival of Mouse Oocytes Following Chemotherapy or Aging by Targeting Bax and Rad51

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