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Examples
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As expected, mutations in K-Ras or B-Raf were often, albeit not always, linked to high Erk1/2 activity.
BioMed Central - Latest articles Theresia Kress 2010
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Cancer Center and Research Institute and Cancer Biology Graduate Program, University of South Florida, Tampa, Florida, concluded that "Evidence is offered for the hypothesis that the early, founding effects of B-Raf mutations on melanoma development occur initially through aneuploidy, before the benefits of activated B-Raf to transformed cell growth and survival can accrue."
THE MEDICAL NEWS Ned Ferguson 2010
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More recently, Plexxikon, Inc., a company that Schlessinger co-founded, has developed an inhibitor of the mutated form of B-Raf.
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More recently, Plexxikon, Inc., a company that Schlessinger co-founded, has developed an inhibitor of the mutated form of B-Raf.
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More recently, Plexxikon, Inc., a company that Schlessinger co-founded, has developed an inhibitor of the mutated form of B-Raf.
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More recently, Plexxikon, Inc., a company that Schlessinger co-founded, has developed an inhibitor of the mutated form of B-Raf.
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The BRAF gene encodes B-Raf proto-oncogene serine/threonine-protein kinase, a protein involved in cell signaling and cellular growth and differentiation.
FierceBiotech 2010
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Selective and potent inhibitors of the mutant B-Raf pathway paradoxically stimulate the MAPK pathway in wild type B-Raf cells
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Karreth successfully generated germline conditional B-Raf V619E mice (V600E in humans) and is using these animals to probe the biology of melanoma in vivo.
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More recently, Plexxikon, Inc., a company that Schlessinger co-founded, has developed an inhibitor of the mutated form of B-Raf.
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