Bcl-xL

Although we noted no changes in the levels of beclin-1 in this study, reduced levels of Bcl-2 and Bcl-xL indicate more beclin-1 is available to activate the enzyme Vps34 and to induce the formation of autophagosomes.

PLoS ONE Alerts: New Articles Tai-Ho Hung et al. 2010

Under this condition, vitamins C and E increase the amounts of Bcl-2 and Bcl-xL, which may inhibit the actions of Bax and Bak, thus reducing apoptosis.

PLoS ONE Alerts: New Articles Tai-Ho Hung et al. 2010

Furthermore, increased levels of Bcl-2 and Bcl-xL in association with a decrease in the autophagy-related protein LC3-II were noted in cytotrophoblastic cells treated with vitamins C and E under standard culture conditions.

PLoS ONE Alerts: New Articles Tai-Ho Hung et al. 2010

We also demonstrated increased levels of Bcl-2 and Bcl-xL in cytotrophoblastic cells treated with vitamins C and E at standard culture conditions.

PLoS ONE Alerts: New Articles Tai-Ho Hung et al. 2010

Vitamin treatment reduced the interactions of beclin-1 with Bcl-2 and Bcl-xL at HR

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However, under HR conditions, which we believe reflect the situation within the placentas of women at risk for preeclampsia, vitamin treatment decreases the amount of Bcl-2 and Bcl-xL, leading to more Bax and Bak present in the mitochondrial membrane to form transition pores with the subsequent release of cytochrome

PLoS ONE Alerts: New Articles Tai-Ho Hung et al. 2010

Figure 5: Bcl-xL overexpression in c-Myb-deficient thymocytes restores survival and rearrangement but not

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In key, Bcl-xL indicates antibody to Bcl-xL plus secondary antibody; 2° Ab indicates secondary antibody alone.

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In contrast, vitamin treatment decreased Bcl-2 and Bcl-xL as well as increased mitochondrial Bak and cytosolic LC3-II in cytotrophoblasts subjected to HR.

PLoS ONE Alerts: New Articles Tai-Ho Hung et al. 2010

On the other hand, the concomitant administration of vitamins C and E decreased Bcl-2 and Bcl-xL levels and increased mitochondrial Bak levels, in addition to increasing of LC3-II in cytotrophoblasts subjected to HR.

PLoS ONE Alerts: New Articles Tai-Ho Hung et al. 2010