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Examples
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In many markets (where available), the Our Bcr-Abl franchise, consisting of Gleevec/Glivec and Tasigna, continued to grow strongly, reaching USD 1.3 billion (+12% cc) in the third quarter.
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Nilotinib is a highly selective Bcr-Abl inhibitor approved for imatinib-resistant chronic myeloid leukemia (CML).
Naturejobs - All Jobs F J Giles 2010
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While Bristol-Myers Squibb Co's Sprycel and Novartis's Tasigna also aim to treat patients after unsuccessful Gleevec treatment, Omapro targets those who test positive for a specific genetic mutation known as the Bcr-Abl T315I mutation.
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While Bristol-Myers Squibb Co's Sprycel and Novartis's Tasigna also aim to treat patients after unsuccessful Gleevec treatment, Omapro targets those who test positive for a specific genetic mutation known as the Bcr-Abl T315I mutation.
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Almost all patients with CML have an abnormality known as the Philadelphia chromosome, which produces a protein called Bcr-Abl.
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ChemGenex Pharmaceuticals a complete response letter regarding its NDA for Omapro ™ for the treatment of adults with chronic myeloid leukemia (CML) who have failed prior therapy with imatinib and have the Bcr-Abl T315I mutation.
GEN News Highlights 2010
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CML patients who have failed imatinib therapy and have the Bcr-Abl T315I mutation.
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Tasigna is a potent and selective inhibitor of the Bcr-Abl protein that causes production of cancer cells in Ph+ CML [2], [3]
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ChemGenex 'application for Omapro is currently under review at the EMEA for CML patients who have failed imatinib therapy and have the Bcr-Abl T315I mutation.
GEN News Highlights 2010
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Bcr-Abl causes malignant white blood cells to proliferate [4].
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